Synthesis Carbidopa

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carbidopa synthesis: gb 940596 ; chemerda et al., u.s. patent 3,462,536 (to merck & co.). l-form: karady et al., de 2062285 ; de 2062332  (1971 merck & co.).



the synthesis begins modified strecker reaction using hydrazine , potassium cyanide on arylacetone (1) give 2. hydrolyzed cold hcl give carboxamide 3. more vigorous hydrolysis 48% hbr cleaves amide bond , aryl ether group produce carbidopa (4).








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