Synthesis Lorcainide

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lorcainide synthesis:



synthesis starts reducing anil formed condensation of p-chloroaniline n-carbethoxy-4-piperidone, sodium borohydride (nabh4). acylated phenacetyl chloride produce amide 2. selective hydrolysis hydrobromic acid (hbr) followed alkylation isopropyl bromide completes synthesis of lorcainide (3).








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